{"id":362,"date":"2020-09-04T18:50:02","date_gmt":"2020-09-04T18:50:02","guid":{"rendered":"https:\/\/www.cairnsurgical.com\/?page_id=362"},"modified":"2025-01-28T17:05:23","modified_gmt":"2025-01-28T17:05:23","slug":"u-s-clinical-trial","status":"publish","type":"page","link":"https:\/\/www.cairnsurgical.com\/others\/u-s-clinical-trial\/","title":{"rendered":"U.S. Clinical Trial"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22.4″ background_image=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/worried1-1.jpg” width=”100%” max_width=”100%” custom_padding=”||41px|||” collapsed=”off”][et_pb_row custom_padding=”0px||33px|||” custom_margin=”1px|auto||auto||” make_equal=”on” custom_css_main_2=”margin: auto;” _builder_version=”3.22.4″][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”Intro text” _builder_version=”3.22.4″ text_font=”|600|||||||” text_text_color=”#000000″ text_font_size=”15px” header_font=”|700|||||||” header_font_size=”46px” text_orientation=”right” custom_margin=”2px||0px|||” custom_padding=”64px||30px|||”]<\/p>\n

Are you frustrated by outcomes in Breast Conserving Surgery?<\/h1>\n

Breast conserving surgery is unsuccessful in removing the entire tumor 20% of the time, resulting in a positive tumor margin upon pathology analysis. This typically means the woman will need to undergo additional surgery.<\/p>\n

A new clinical trial is studying whether the investigational Breast Cancer Locator System used during surgery can improve a surgeon\u2019s ability to reduce positive margins.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”#sites” button_text=”Find A Clinical Trial Site” button_alignment=”center” admin_label=”learn more button” _builder_version=”3.22.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ff3f89″ button_font=”||||||||” custom_margin=”8px||-2px|||” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#75002e”][\/et_pb_button][et_pb_button button_url=”#forpatients” button_text=”Subjects – Click Here” button_alignment=”center” admin_label=”patients button” _builder_version=”3.22.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ff3f89″ button_font=”||||||||” custom_margin=”18px||0px|||” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#75002e”][\/et_pb_button][et_pb_button button_url=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2021\/09\/cairnsurgical-BCL-brochure.pdf” url_new_window=”on” button_text=”Download Brochure” button_alignment=”center” admin_label=”patients button” _builder_version=”3.22.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ff3f89″ button_font=”||||||||” custom_margin=”18px||0px|||” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#75002e”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.22.4″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ background_color=”#f0f0f0″ custom_padding=”||5px|||” collapsed=”off”][et_pb_row custom_padding=”||1px|||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text admin_label=”about the trial text” _builder_version=”3.22.4″ min_height=”129px” custom_margin=”||25px|||” custom_padding=”30px||0px|||”]<\/p>\n

About the Breast Cancer Locator Trial<\/h1>\n

The Breast Cancer Locator Trial is a prospective, multicenter, 1:1 randomized, controlled pivotal trial of the Breast Cancer Locator System used to guide partial mastectomy for breast cancer compared to traditional wire localization.[\/et_pb_text][et_pb_text _builder_version=”3.22.4″ header_font=”||||||||” header_5_font=”|700|||||||” header_5_text_align=”left” header_5_text_color=”#565656″ header_6_font=”|700|||||||”]<\/p>\n

Target Enrollment:<\/h5>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”4px|||||” _builder_version=”3.22.4″][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/woman-icon.png” admin_label=”448 women image” _builder_version=”3.22.4″ max_width=”12%” module_alignment=”center” custom_margin=”||18px|||”][\/et_pb_image][et_pb_text _builder_version=”3.22.4″ text_font=”|700|||||||” text_text_color=”#ff3f89″ text_font_size=”17px” custom_margin=”-4px|||||”]<\/p>\n

452 Women<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/health-pink.png” admin_label=”us centers image” _builder_version=”3.22.4″ max_width=”12%” module_alignment=”center” custom_margin=”||18px|||” filter_saturate=”0%” filter_brightness=”78%”][\/et_pb_image][et_pb_text _builder_version=”3.22.4″ text_font=”|700|||||||” text_font_size=”17px” custom_margin=”-4px|||||”]<\/p>\n

30 U.S. Centers<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”6px|||||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text admin_label=”about the trial text” _builder_version=”3.22.4″ text_font=”||||||||” min_height=”99px” custom_margin=”||-4px|||” custom_padding=”1px||0px|||”]A roll-in phase encompassing up to 30 additional patients (maximum of 1 patient per site) may be included from centers that do not have previous experience with the BCL before randomization begins.<\/span>[\/et_pb_text][et_pb_text admin_label=”endpoints title” _builder_version=”3.22.4″ custom_margin=”2px|||||”]<\/p>\n

Endpoints<\/strong><\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=”on” gutter_width=”1″ custom_padding=”0px||0px|||” custom_margin=”0px|auto||auto||” make_equal=”on” padding_top_1=”0px” padding_top_2=”0px” padding_right_1=”0px” padding_right_2=”0px” padding_bottom_1=”0px” padding_bottom_2=”0px” padding_left_1=”0px” padding_left_2=”0px” _builder_version=”3.22.4″ background_color=”#ffffff” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#ff3f89″ box_shadow_style=”preset1″ box_shadow_blur=”50px” box_shadow_spread=”-18px”][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”who is the right patient text – inclusion” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” border_radii=”on|12px|12px|12px|12px” border_color_all=”#d1d1d1″ border_style_all=”dashed” height=”100%” custom_padding=”44px|44px|33px|44px||”]<\/p>\n

Primary Endpoint<\/span><\/h5>\n
    \n
  • Positive margin rate in comparison to traditional wire localization<\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”who is the right patient text – inclusion” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” border_color_all=”#d1d1d1″ border_style_all=”dashed” border_width_left=”1px” border_style_left=”solid” custom_padding=”44px|44px|31px|44px||”]<\/p>\n

    Other Endpoints<\/span><\/h5>\n
      \n
    • Specimen volumes<\/li>\n
    • Rate of additional shave biopsies<\/li>\n
    • Re-excision rate<\/li>\n
    • Cancer localization rate<\/li>\n
    • Operative time<\/li>\n
    • Cost of care<\/li>\n
    • Adverse events<\/li>\n<\/ul>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”57px|||||” custom_margin=”25px||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text _builder_version=”3.22.4″ text_font=”||||||||” custom_margin=”30px||20px”]<\/p>\n

      Who is the right subject?<\/strong><\/h4>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=”on” gutter_width=”1″ custom_padding=”0px||0px|||” custom_margin=”0px|auto||auto||” make_equal=”on” padding_top_1=”0px” padding_top_2=”0px” padding_right_1=”0px” padding_right_2=”0px” padding_bottom_1=”0px” padding_bottom_2=”0px” padding_left_1=”0px” padding_left_2=”0px” _builder_version=”3.22.4″ background_color=”#ffffff” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#ff3f89 ” box_shadow_style=”preset1″ box_shadow_blur=”50px” box_shadow_spread=”-18px”][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”who is the right patient text – inclusion” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” border_radii=”on|12px|12px|12px|12px” border_color_all=”#d1d1d1″ border_style_all=”dashed” height=”100%” custom_padding=”44px|44px|33px|44px||”]<\/p>\n

      Key inclusion criteria<\/span><\/h5>\n
        \n
      • Women >18 years<\/li>\n
      • Histologic diagnosis of invasive breast cancer or DCIS<\/li>\n
      • Non-palpable, unifocal tumor or multifocal tumor with satellite lesions \u2264 2cm from primary tumor<\/li>\n
      • Tumor \u2265 0.8 cm in diameter visible on prone breast MRI imaging<\/li>\n<\/ul>\n

        [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”who is the right patient text – inclusion” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” border_color_all=”#d1d1d1″ border_style_all=”dashed” border_width_left=”1px” border_style_left=”solid” custom_padding=”44px|44px|33px|44px||”]<\/p>\n

        Key exclusion criteria<\/span><\/h5>\n
          \n
        • Absolute contraindication to MRI, including presence of implanted medical device (e.g., pacemaker or neurostimulator), aneurysm clip, or metallic foreign body in or near eyes<\/li>\n
        • Contraindication to use of gadolinium-based intravenous contrast, including life-threatening allergy<\/li>\n
        • Severe claustrophobia that precludes prone or supine MRI<\/span><\/li>\n
        • Compromised renal function, including chronic, severe kidney disease or acute kidney injury<\/span><\/li>\n
        • Pregnancy<\/span><\/li>\n
        • Previous or planned neoadjuvant chemotherapy<\/span><\/li>\n
        • Sternal notch-to-nipple distance of > 32cm<\/span><\/li>\n
        • > 135cm circumference around breasts and arms for sites using 60cm bore scanners, and > 145 cm for sites using 70cm bore scanners<\/span><\/li>\n
        • Known allergy to materials in device<\/span><\/li>\n
        • Use of localization with devices other than a localization wire<\/span><\/li>\n
        • Would require > 2 localization wires, if randomized to standard of care arm<\/li>\n
        • Multicentric tumors (additional tumors > 2cm from primary tumor)<\/span><\/li>\n
        • Would require chest wall muscle nerve block as part of the operation<\/li>\n<\/ul>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3px||80px|||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_button button_url=”#sites” button_text=”Find A Clinical Trial Site” button_alignment=”center” admin_label=”learn more button” _builder_version=”3.22.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ff3f89″ button_font=”||||||||” custom_margin=”67px||0px|||” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#75002e”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ custom_padding=”3px||2px|||” collapsed=”off”][et_pb_row custom_padding=”||1px|||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text admin_label=”about bcl title” _builder_version=”3.22.4″ custom_margin=”33px||30px|||” custom_padding=”18px||2px|||”]<\/p>\n

          About the Breast Cancer Locator<\/h1>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.22.4″][et_pb_column type=”3_5″ _builder_version=”3.22.4″][et_pb_testimonial quote_icon=”off” _builder_version=”3.22.4″ body_font=”||||||||” body_font_size=”17px” body_line_height=”1.7em” background_color=”rgba(245,245,245,0.95)” border_radii=”||||” border_color_all=”#019e9e” border_width_left=”7px” border_color_left=”#ff3f89″ box_shadow_style=”preset1″ box_shadow_blur=”74px” box_shadow_spread=”-18px” box_shadow_color=”rgba(0,0,0,0.48)” custom_margin=”9vw|-5vw||0vw” custom_padding=”64px|66px||66px” z_index=”79″]“Breast cancer surgery today leaves cancer in the breast in more than one in five cases \u2013 as a surgeon myself, that\u2019s just unacceptable. Positive tumor margins, and thus, typically, re-excision surgery to go back into the breast, is bad for the patient, and it\u2019s expensive and it\u2019s painful. We invented the Breast Cancer Locator with the vision to enable a surgeon to reduce positive tumor margins.”<\/em>[\/et_pb_testimonial][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/barth.jpg” admin_label=”barth image” _builder_version=”3.22.4″ custom_margin=”||0px|||” z_index=”0″][\/et_pb_image][et_pb_text admin_label=”barth descr” module_class=”dr-brt” _builder_version=”3.22.4″ text_font=”||||||||” text_text_color=”#fff” text_font_size=”11px” text_line_height=”1.5em” header_font=”||||||||” header_5_font=”||||||||” header_5_text_color=”#ffffff” background_color=”#494949″ background_color_gradient_direction=”100deg” box_shadow_style=”preset1″ box_shadow_blur=”80px” custom_margin=”0px||” custom_padding=”22px|26px|22px|26px||true”]<\/p>\n

          Richard Barth, Jr., MD<\/strong><\/h5>\n

          Chief of General Surgery, Dartmouth-Hitchcock Medical Center
          \nProfessor of Surgery, Geisel School of Medicine at Dartmouth
          \nCo-founder, CairnSurgical (developer of the Breast Cancer Locator)<\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”||3px|||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text admin_label=”bcl steps text” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”16px” custom_margin=”40px||45px|||”]The problem is that current wire localization techniques used ahead of surgery, and implantable seeds and tags, do not facilitate precise surgery. They tell surgeons nothing about tumor size, shape, edges or margins. The Breast Cancer Locator System includes three steps:[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”||76px|||” _builder_version=”3.22.4″][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/trio1-1.png” admin_label=”bcl image 1″ _builder_version=”3.22.4″][\/et_pb_image][et_pb_text _builder_version=”3.22.4″ custom_padding=”|||46px”]<\/p>\n

          A supine MRI<\/strong> image is first performed with the breast positioned in its surgical position providing precise detail on the size, shape, depth, edges and 1 centimeter margin for the tumor. This imagery is used to analyze the tumor and construct a three-dimensional tumor model that serves as the basis for two surgical tools.<\/p>\n

          [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/trio2.png” admin_label=”bcl image 2″ _builder_version=”3.22.4″][\/et_pb_image][et_pb_text _builder_version=”3.22.4″ custom_padding=”|||46px”]A 3D-printed form<\/strong> \u2013 the Breast Cancer Locator, or BCL \u2013 is produced that fits the unique shape of the patient\u2019s breast, with ports for central and bracketing wires placed under anesthesia in surgery. This is designed to guide the surgeon to the precise tumor boundaries and margins.[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/trio3.png” admin_label=”bcl image 3″ _builder_version=”3.22.4″][\/et_pb_image][et_pb_text _builder_version=”3.22.4″ custom_padding=”|||46px”]An interactive 3D image<\/strong> \u2013 the Visualizer \u2013 offers visualization of the tumor and quantification of the closest distance from the tumor to the skin and chest wall.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ background_color=”#f2f2f2″ custom_padding=”3px||55px|||” collapsed=”off”][et_pb_row _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers title” module_id=”sites” _builder_version=”3.22.4″ text_font=”||||||||” min_height=”20px” custom_margin=”0px||39px|||” custom_padding=”50px|||||”]<\/p>\n

          Participating Centers<\/h1>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”||0px|||” custom_margin=”|auto|11px|auto||” _builder_version=”3.22.4″][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” custom_padding=”||0px|||”]Dartmouth-Hitchcock Nashua<\/strong>
          \nSt. Joseph Hospital Rehabilitation
          \n2300 Southwood Drive
          \nNashua, NH 03063
          \nPh: 603.577.4171[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” custom_padding=”||0px|||”]Catholic Medical Center – Breast Care Center<\/strong>
          \nBedford Medical Park
          \n9 Washington Place
          \nBedford, NH 03110
          \nPh: 603.663.5270[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em” custom_padding=”||0px|||”]Massachusetts General\/North Shore Center for Outpatient Car<\/strong>e
          \n104 Endicott Street, Suite 200
          \nDanvers, MA 01923
          \nPh: 978.882.6899[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]MD Anderson Cancer Center<\/strong>
          \nBreast Surgical Oncology
          \n1400 Pressler Unit 1434
          \nHouston, TX 77030-4008
          \nPh: 713.792.5031[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Baptist MD Anderson Cancer Center<\/strong>
          \n1301 Palm Avenue
          \nJacksonville, FL \u00a032207
          \nPh: 904.202.7070[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Comprehensive Breast Center<\/strong>
          \nA Division of Arizona Center for Cancer Care
          \n9965 N. 95 th
          \nSt, Suite 105
          \nScottsdale, AZ 85258
          \nPh: 480.278.8261[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Women and Infants Program in Women’s Oncology Breast Health Center<\/strong>
          \n101 Dudley Street
          \nProvidence, RI 02905
          \nPh: 401.453.7540[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Norris Cotton Cancer Center<\/strong>
          \nDartmouth-Hitchcock Medical Center
          \nOne Medical Center Drive
          \nLebanon, NH 03756-3500
          \nPh: 603.650.4344[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Cheshire Medical Center Dartmouth-Hitchcock Keene General Surgery<\/strong>
          \n580 Court St
          \nKeene, NH 03431
          \nPh: 603.354.5469[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”9px|||||” _builder_version=”3.22.4″][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Moffitt Cancer Center Magnolia Campus<\/strong>
          \n12902 USF Magnolia Drive
          \nTampa, FL 33612
          \nPh: 813.745.4673[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]St Peter’s Health Partners Cancer Care Center<\/strong>
          \n317 South Manning Boulevard, Suite 220
          \nAlbany, New York 12208
          \nPh: 518.525.6739[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Royal Free Hospital<\/strong>
          \nPond St
          \nLondon NW3 2QG,
          \nUnited Kingdom
          \nPh: +44.20.7794.0500[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”9px|||||” _builder_version=”3.22.4″][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Kent Hospital<\/strong>
          \n455 Toll Gate Rd
          \nWarwick, RI 02886
          \nPh: 401.737.7000[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Manchester University NHS Foundation Trust,<\/strong>
          \n1 st Floor NOWGEN Centre
          \nNightingale Centre Southmoor Road
          \nManchester M239LT
          \n0300 33 9444[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Princess Margaret Cancer Centre<\/strong>
          \nUniversity Health Network – PMH
          \n610 University Ave, 3-130
          \nToronto, Ontario Canada, M5G 2M9
          \nPh: 416.946.2292[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Hennepin Healthcare<\/strong>
          \n701 Park Ave
          \nMinneapolis,
          \nMN 55415
          \nPh: 612.873.5300[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Tufts University<\/strong>
          \n860 Washington St
          \nBoston,
          \nMA 02111[\/et_pb_text][et_pb_text admin_label=”participating centers list 1″ _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Columbia University Irving Medical Center and New York-Presbyterian Hospital<\/strong>
          \n161 Fort Washington Avenue
          \nNew York, NY 10032
          \nPh: 212.305.9676[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_text _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]The Ohio State University Comprehensive Cancer Center<\/strong>
          \n460 W. 10th Avenue
          \nColumbus, OH 43212
          \nPh: 614.293.4040[\/et_pb_text][et_pb_text _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Summit Health<\/strong>
          \n150 Park Ave
          \nFlorham Park, NJ 07932
          \nPh: 970.404.9945[\/et_pb_text][et_pb_text _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”12px” text_line_height=”1.4em”]Inova Schar Cancer Institute<\/strong>
          \n8081 Innovation Park Drive
          \nFairfax, VA 22031
          \nPh: 571.506.8252[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ width=”100%” max_width=”100%” custom_padding=”38px||2px|||” collapsed=”off”][et_pb_row custom_padding=”0px||28px|||” custom_margin=”1px|auto||auto||” make_equal=”on” custom_css_main_2=”margin: auto;” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_text admin_label=”for patients title” module_id=”forpatients” _builder_version=”3.22.4″ text_font=”|600|||||||” text_text_color=”#ffffff” text_font_size=”15px” header_font=”||||||||” header_text_color=”#000000″ header_font_size=”31px” header_5_font=”||||||||” header_5_text_color=”#000000″ header_5_font_size=”20px” text_orientation=”right” custom_margin=”2px|||||” custom_padding=”53px||4px|||”]<\/p>\n

          For Subjects<\/h1>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ custom_padding=”3px||7px|||” collapsed=”off”][et_pb_row custom_padding=”8px||3px|||” _builder_version=”3.22.4″][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/wmsq1.jpg” _builder_version=”3.22.4″][\/et_pb_image][et_pb_text admin_label=”breast cancer text” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”16px” custom_margin=”||57px|||”]12% of women\u00a0<\/strong>develop invasive breast cancer during their lifetime.[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/irregular-tumor-1.png” admin_label=”stats image 2″ _builder_version=”3.22.4″][\/et_pb_image][et_pb_text admin_label=”breast cancer text” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”16px” custom_margin=”||57px|||”]80% of breast cancer tumors\u00a0<\/strong>are irregularly shaped, making it difficult for surgeons to identify the tumor edges and margins.[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/surgeon.png” admin_label=”stats image 3″ _builder_version=”3.22.4″][\/et_pb_image][et_pb_text admin_label=”breast cancer text” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”16px” custom_margin=”||57px|||”]20% of<\/strong>\u00a0breast conserving surgeries will result in positive tumor margins upon pathology analysis, which could mean that some cancer is remaining in the breast.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ custom_padding=”3px||7px|||” collapsed=”off”][et_pb_row custom_padding=”25px||29px|||” make_equal=”on” custom_css_main_2=”align-self: center;” _builder_version=”3.22.4″][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/lifestyle1.jpg” _builder_version=”3.22.4″ border_width_left=”6px” border_color_left=”#ff3f89″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”breast cancer text” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”16px”]About one in eight women will develop invasive breast cancer during her lifetime.<\/strong><\/p>\n

          Breast conserving surgery is successful about 80 percent of the time in removing the entire tumor. However, one in five women with breast cancer must undergo a second surgery when some of the cancer is missed.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” custom_css_main_1=”align-self: center;” _builder_version=”3.22.4″][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”breast cancer text” _builder_version=”3.22.4″ text_font=”||||||||” text_font_size=”16px”]The issue is not a surgeon\u2019s skills; it is the lack of technology to provide enough information about the tumor to aid the surgeon.<\/strong><\/p>\n

          According to a recent study on breast cancer tumor shapes, fewer than 20 percent of breast cancer tumors are round. When the shape is irregular, it can be challenging for surgeons to easily identify its edges in order to remove all of it.<\/p>\n

          A new clinical trial is studying whether the investigational Breast Cancer Locator System used during surgery can improve a surgeon\u2019s ability to reduce positive margins.[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_image src=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/vert-wm1-2.jpg” _builder_version=”3.22.4″ border_width_right=”6px” border_color_right=”#ff3f89″ border_color_left=”#ff3f89″][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22.4″ custom_padding=”3px||7px|||” collapsed=”off”][et_pb_row custom_padding=”30px||57px|||” _builder_version=”3.22.4″][et_pb_column type=”4_4″ _builder_version=”3.22.4″][et_pb_button button_url=”#sites” button_text=”Find A Clinical Trial Site” button_alignment=”center” admin_label=”find site button” _builder_version=”3.22.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ff3f89″ button_font=”||||||||” custom_margin=”23px||81px|||” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#75002e”][\/et_pb_button][et_pb_text _builder_version=”3.22.4″ text_font=”||||||||” text_text_color=”#8e8e8e” text_font_size=”12px”]<\/p>\n

          CAUTION – Investigational device. Limited by Federal (or United States) law to investigational use<\/p>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

          [et_pb_section fb_built=”1″ _builder_version=”3.22.4″ background_image=”https:\/\/www.cairnsurgical.com\/others\/wp-content\/uploads\/2020\/09\/worried1-1.jpg” width=”100%” max_width=”100%” custom_padding=”||41px|||” collapsed=”off”][et_pb_row custom_padding=”0px||33px|||” custom_margin=”1px|auto||auto||” make_equal=”on” custom_css_main_2=”margin: auto;” _builder_version=”3.22.4″][et_pb_column type=”1_2″ _builder_version=”3.22.4″][et_pb_text admin_label=”Intro text” _builder_version=”3.22.4″ text_font=”|600|||||||” text_text_color=”#000000″ text_font_size=”15px” header_font=”|700|||||||” header_font_size=”46px” text_orientation=”right” custom_margin=”2px||0px|||” custom_padding=”64px||30px|||”] Are you frustrated by outcomes in Breast Conserving Surgery? Breast conserving surgery is unsuccessful in removing the entire tumor 20% of the time, resulting in a positive tumor […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/pages\/362"}],"collection":[{"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/comments?post=362"}],"version-history":[{"count":127,"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/pages\/362\/revisions"}],"predecessor-version":[{"id":793,"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/pages\/362\/revisions\/793"}],"wp:attachment":[{"href":"https:\/\/www.cairnsurgical.com\/others\/wp-json\/wp\/v2\/media?parent=362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}